Regulation of Staphylococcal Enterotoxin B: Effect of Anaerobic Shock
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چکیده
منابع مشابه
Intranasal Rapamycin Rescues Mice from Staphylococcal Enterotoxin B-Induced Shock
Staphylococcal enterotoxin B (SEB) and related exotoxins produced by Staphylococcus aureus are potent activators of the immune system and cause toxic shock in humans. Currently there is no effective treatment except for the use of intravenous immunoglobulins administered shortly after SEB exposure. Intranasal SEB induces long-lasting lung injury which requires prolonged drug treatment. We inves...
متن کاملFactors affecting the regulation of staphylococcal enterotoxin B.
Several factors which regulate the synthesis of enterotoxin B were examined in Staphylococcus aureus S-6 and in its heme-requiring mutant S-6H2. The kinetics of enterotoxin B synthesis during anaerobic growth were identical to those observed under aerobic conditions; extracellular enterotoxin accumulated in the medium during the transition between exponential and stationary phase growth. Strain...
متن کاملNeutralization of Staphylococcal enterotoxin B by aptamer
12 Staphylococcal enterotoxin B (SEB) is a major virulence factor for 13 Staphylococcal toxic shock syndrome (TSS). SEB activates a large subset of the T 14 lymphocytic population, releasing pro-inflammatory cytokines. Blocking 15 SEB-initiated toxicity may be an effective strategy for treating TSS. Using a 16 systematic evolution of ligands by exponential enrichment (SELEX) process, we 17 iden...
متن کاملPurification of Type B Staphylococcal Enterotoxin.
Frea, James I. (University of Wisconsin, Madison), Elizabeth McCoy, and F. M. Strong. Purification of type B staphylococcal enterotoxin. J. Bacteriol. 86:1308-1313. 1963.-A procedure for the production and isolation of type B staphylococcal enterotoxin in yields up to 4 mg per liter of toxic culture is presented. Staphylococcus aureus S6 was grown in shake flask cultures at 37 C for 24 hr in a ...
متن کاملHydrogen ion equilibrai of staphylococcal enterotoxin B.
Potentiometric and spectrophotometric titrations of staphylococcal enterotoxin B have been carried out in 0.16 M KC1 at 25”. Potentiometric titration results indicate that the titration curves are essentially reversible between pH 1.50 and 11.0. All of the ionizable groups in enterotoxin B found from the titration curves are consistent with the amino acid composition which has been reported in ...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1973
ISSN: 0003-6919
DOI: 10.1128/am.25.4.553-557.1973